- Farrah Laurel Abraham, (b. 1991, Omaha)
- Wesley Addy (b. Omaha 1913– d. Danbury, Connecticut, 1996), actor
- James Adomian, (b. 1980, Omaha)
- Craig Anton, (b. 1962, Omaha) actor
- Karen Jensen (Arthur) (Omaha, 1941) TV, Movie and Theatre director and actress
- Adele Astaire (1897–1981), dancer and entertainer
- Fred Astaire (1899–1987), dancer and actor
- Pamela Austin, b. 1941, Omaha)
- Ray Baker (1948–), actor, Cybill
- Reginald Barnes, (b. 1980, Omaha) actor
- Buddy Bear, (b. 1915, Omaha) actor (brother of Max Bear)
- Max Bear, (b. 1909, Omaha) actor
- John Beasley (1943–), actor, Everwood
- Michael Biehn (1956–), actor
- Lindsay Bloom, (b. 1950, Omaha) actress
- Ward Bond (1903–1960), actor
- Steve Borden (Sting), (b. 1959, Omaha) WCW 10 X World Title
- Marlon Brando (1924–2004), Academy Award-winning actor
- Justin Bruening (1979–), actor, All My Children, Knight Rider
- Warren Buffett, (b. 1930, Omaha) Investor/ TV and movie appearances
- Montgomery Clift (1920–1966), actor
- Abbie Cobb, actress, Suburgatory
- James Coburn (1928–2002), actor
- Francis Corby, (b. 1893, Omaha) Director, Cinematographer, Writer, member ASC
- James M. Connor (1960–), actor
- Daniel Covin (1993-), actor All My Children
- Harry Culver (1880 – 1946) b. Milford, NE, Culver played a vital role in the development of all three of “The Heart of Screenland”‘s major movies studios.
- Nicholas D’Agosto, (b. Omaha, 1980)
- Cherien Dabis, (b.Omaha, 1976) actress
- Sandy Dennis (1937–1992), b. Hastings, NE, actress
- David Doyle (1929–1997), actor
- Mary Doyle (1931–1995), actress
- Christopher B. Duncan (1964–), actor, The Jamie Foxx Show, The District, Aliens in America
- Leslie Easterbrook (born 1949), actress
- Mauro Fiore – (b. Marzi, Calabria, Italy, 1964)
- Jim Fitzpatrick (born 1959), actor, All My Children
- Henry Fonda (1905–1982), Academy Award-winning actor
- John. P. Fulton (1902-1966), Special Effects and Cinematographer, 250 Hollywood films
- Jorge Garcia, Omaha, (1973–), actor
- Hoot Gibson (1892–1962), actor and rodeo cowboy
- Randy J. Goodwin, (b. 1967, Omaha)
- Coleen Gray (1922–), actress
- Bryan Greenberg (born 1978), actor, musician, One Tree Hill, October Road, How to Make It in America
- Elizabeth Gudenrath, (Omaha) actress
- Lacey Hannan, (b. 1987, Omaha) actress
- Charles Bert Hayward (b. 1920, Hyannis, – 1998), motion picture stuntman and actor
- Leland Hayward (1902–1971), Hollywood and Broadway agent and producer
- Jean Heather, (b. 1921, Omaha) actress
- Marg Helgenberger (1958–), actress
- Brad William Henke (1971–), actor, October Road, Nikki, Lost
- Hallee Hirsh (1987–), actress, Flight 29 Down, JAG, ER
- Virginia Huston (1925–1981), actress
- Vivi Janiss, (b. 1911, Omaha) actress
- David Janssen (1931–1980), actor
- Jay Karnes (1963–), actor, Det. “Dutch” Wagenbach on The Shield
- Jaime King (1979–), actress
- Emily Kinney, Wayne, (1985–), actress
- Terry Kiser, (b.1939, Omaha)
- Chris Klein, (b. Lincoln, 1979), actor
- Swoosie Kurtz (1944–), actress
- Harold Lloyd (1893–1971), actor and comedian
- Pierce Lyden (1908–1998), actor
- Gordon MacRae (1921–1986), actor and singer
- Lisa Masters, (b. 1964, Omaha) actress
- Holt McCallany (1964–), actor, Lights Out, Freedom, CSI: Miami
- Dorothy McGuire (1916–2001), actress
- Andy Milder, (b. 1969, Omaha)
- Reed Morano, (b. 1977, Omaha) Director
- Fred Niblo (1874–1948), actor, director, and producer
- Nick Nolte (1941–), actor and producer
- Alexander Payne (1961–), director and screenwriter
- Lenka Peterson (1925–), actress
- Scott Porter (1979–), actor, Friday Night Lights, The Good Wife, Hart of Dixie
- Anne Ramsey (1929–1988), actress
- Andrew Rannels, Omaha, (1978–), actor
- Thurl Ravenscroft (1914–2005), b. Norfolk, voice actor and singer
- Bill Ray, (1936-2020) b. Columbus, Famous for photographing Hollywood Movie Stars
- Andy Roddick, (b. 1982, Omaha) actor
- Angelo Rositto, (b. 1908, Omaha) actor
- Yolanda Ross, (b. Omaha) actress
- Nicholas Sparks, (b. 1965, Omaha) Writer
- Rebecca Staab (1961–), actress, former beauty queen, Live Shot
- Lillinan St. Cyr, (Red Wing) b. Winnebago Reservation 1884, married to possible Algonquian native of Delaware, James Young Deer
- Hilary Swank (1974–), two-time Academy Award-winning actress
- Inga Swenson (1932–), actress
- Robert Taylor (1911–1969), actor
- Donald E. Thorin born 1934 in Omaha, cinematographer
- Janine Turner (1962–), actress
- John Trudell Born on February 15, 1946 in Omaha. Civil Rights Actor, Musician, performer, subject of film documentary.
- Gabrielle Union (1973–), actress
- Lucky Vanous (1961–), model, actor, Pacific Palisades
- Charles Weidman (1901–1975), dancer and choreographer
- Lynn “Red” Williams, (b. 1963, Omaha) professional football player, actor
- James Young Deer aka James Young Johnson ( b. 1878 Washington D.C.), producer/director of westerns silent screen era Hollywood
- Darryl F. Zanuck (1902–1979), producer, writer, actor and director
- Crystal Carson — (born June 24, 1967) General Hospital for 6 years, 1991-1997 as Julia Barrett
- Dick Cavett (1936–), television talk show host
- Floyd Kalber (1924–2004), television journalist and anchorman
- Lindsey Shaw (1989–), child actor for Ned’s Declassified School Survival Guide, born in Lincoln
- Kim Winona (1930–1978), actress who portrayed Morning Star on CBS’s Brave Eagle (1955–1956)
- JoAnn Young – award winning writer/producer/director, Mr. Rogers Documentary
- Malcom X, (b. 1925, Omaha – Writer, Human Rights Activist
- Paula Zahn (1956–), news anchor for CNN
- James Adomian (1980–), actor, stand-up comedian
- Johnny Carson (1925–2005), comedian
- Adam DeVine, actor, comedian, writer, Workaholics
- Godfrey (1969–), comedian, actor
- Larry the Cable Guy (1963–), comedian
- Angela V. Shelton, actress, comedienne
- Roger Welsch (1936–), author, humorist, and folklorist
- 311, rock band
- Remedy Drive, rock band
- VOTA (formerly Casting Pearls), rock band
- Kianna Alarid (1978–), lead singer for band Tilly and the Wall
- Roni Benise, flamenco guitarist
- Ruth Etting (1896–1976), singer and actress
- Todd Fink (1974–), member of the band The Faint
- Chip Davis (1947–), singer-songwriter, founder of Mannheim Steamroller, and president and CEO of American Gramaphone
- Amy Heidemann, member of the band Karmin, graduated from Seward High School in Seward, Nebraska
- Howard Hanson (1896–1981), composer and conductor
- Wynonie “Mr. Blues” Harris (1915–1969), rhythm and blues singer
- Neal Hefti (1922–), jazz trumpeter and composer
- Neely Jenkins (1974–), member of band Tilly and the Wall
- Tim Kasher (1976–), singer
- Matty Lewis (1975–), singer/guitarist
- Tom May (b. Nebraska) Folk Singer, songwriter, author, creator of River City Folk a syndicated radio program
- Randy Meisner (1946-), singer, songwriter, founding member of the Eagles and Poco
- Conor Oberst (1980–), singer-songwriter with Bright Eyes
- Bryan Olesen (1973–), singer/guitarist of VOTA, former member of Newsboys
- Charlie Pettis, Bluegrass and Folk musician
- Jamie Pressnall (1976–), member of band Tilly and the Wall
- Paul Revere (January 7, 1938–) born in Harvard, Clay County. Musician, teen idol. Founder Paul Revere and the Raiders.
- Ann Ronell (1906 or 1908–1993), jazz composer and lyricist
- Josh Rouse (1972–), singer-songwriter
- Elliott Smith (1969–2003), singer-songwriter
- Ryland Steen (1980–) Reel Big Fish drummer
- Matthew Sweet (1964–), rock musician
- John Trudell Born on February 15, 1946 in Omaha. Poet, Performer, Musician. Leader AKA Graffiti Band.
- James Valentine (1978–), Maroon 5 guitarist
- Paul Williams (1940–), singer-songwriter
- Roger Williams (1925–), pianist
- Zager and Evans (Rick Evans and Denny Zager), rock band made famous by hit song In the Year 2525 in 1969.
